Autore
SABRINA TALIANI
Unimap Dati autore
- Ricercatore Universitario presso Dipartimento di Scienze Farmaceutiche
- Membro della Facolta' di Farmacia
- Settore scientifico disciplinare CHIM/08 CHIMICA FARMACEUTICA
- In servizio
Prodotti
- Abstract
- Articoli
- "Isosteric replacement of the indole nucleus by benzothiophene and benzofuran in a series of indolylglyoxylylamine derivatives with partial agonist activity at the benzodiazepine receptor." 1996
- 3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands. 2000
- Effects of newly-developed benzodiazepine ligands on noise-induced mitochondrial damage in the rat myocardium. 2000
- Synthesis of a novel purine-containing heterocyclic ring system: 8,10-dimethylindolo[2',3':5,6][1,2,4]triazino[4,3-f]purine-9,11(8H,10H,13H)-dione. 2000
- 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: A New Class of Selective A1 Adenosine Receptor Antagonists 2001
- Novel N-(Arylalkyl)indol-3-ylglyoxylylamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis Biological Evaluation, and Molecular Modeling Analysis of the structure-Activity Relationships 2001
- [1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: A New Class of Selective Aldose Reductase Inhibitors 2001
- Geometrically Constrained Analogues of N-Benzylindolylglyoxylylamides: [1, 2,4]Triazino[4, 3-a]benzimidazol-4(10H)-one Derivatives as Potential New Ligands at the Benzodiazepine Receptor. 2003
- Synthesis of Pyrimido[1,2-a]benzimidazol-4(10H)-one Derivatives and Evaluation of their Interactions with DNA 2003
- A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites. 2004
- N,N-Dialkyl-2-phenylindol-3- ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Benzodiazepine Receptor 2004
- 2-(Benzimidazol-2-yl)quinoxalines: A Novel Class of selective Antagonists at Human A1 and A3 Adenosine Receptors Designed by 3D Database Searching 2005
- High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives 2005
- Naphtho[1,2-d]isothiazole Acetic Acid Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors 2005
- Novel, Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synhesis, Structure-Activity Relationships, and Molecular Modeling Studies. 2005
- Synthesis and Benzodiazepine Receptor Affinity of Derivatives of the New Tricyclic Heteroaromatic System Pyrido[3',2':5,6]thiopyrano[4,3-c]pyridazin-3(2H,5H)-one. 2005
- Synthesis of New Hetrocyclic Ring Systems via [1,3,5]Triazino[1,2-a]benzimidazole Derivatives 2005
- Refinement of the Benzodiazepine Receptor Site Topology by Structure-Activity Relationships of New N-(Heteroarylmethyl)indol-3-ylglyoxylamides 2006
- 5-Amino-2-phenyl1,2,3triazolo1,2-a1,2,4benzotriazin-1-one: A Versatile Scaffold To Obtain Potent and Selective A3 Adenosine Receptor Antagonists 2007
- GABAA/Bz receptor subtypes as targets for selective drugs. 2007
- New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation 2007
- Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands. 2007
- Pyrido-1,2-a-pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose reductase Inhibitors Exhibiting Antioxidant Activity 2007
- Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model. 2008
- Anxiolytic-like effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of Translocator Protein promoting neurosteroid biosynthesis. 2008
- Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists. 2008
- Highlighting the New Advances in Drug Discovery and Development 2008
- Synthesis and in vitro Antiproliferative Activity of New Substituted Benzo3',2':5,6thiopyrano4,3-dpyrimidines. 2008
- A virtual screening study of the 18-kDa translocator protein using pharmacophore models combined with 3D-QSAR studies 2009
- Benzothiopyranoindole-Based Antiproliferative Agents: Synthesis, Cytotoxicity, Nucleic Acids Interaction, and Topoisomerases Inhibition Properties 2009
- Exploiting the Pyrazolo3,4-dpyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors 2009
- Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. 2009
- Translocator protein ligands as promising therapeutic tools for anxiety disorders. 2009
- A(3) Receptor Ligands: Past, Present and Future Trends 2010
- Allosteric Modulators for Adenosine Receptors: An Alternative to the Orthosteric Ligands. 2010
- Novel N2-substituted pyrazolo3,4-dpyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. 2010
- Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization. 2010
- Recent Advances in the Development of Dual Topoisomerase I and II Inhibitors as Anticancer Drugs. 2010
- Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABA(A) receptor activity. 2011
- Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A(1) Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility. 2011
- Evaluation of Novel N1-Methyl-2-phenylindol-3-ylglyoxylamides as a New Chemotype 2 of 18 kDa Translocator Protein-Selective Ligand Suitable for the Development 3 of Positron Emission Tomography Radioligands. 2011
- Structural requirements to obtain highly potent and selective 18 kDa Translocator Protein (TSPO) ligands. 2011
- Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 2011
- Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization 2012
- Atti, Riassunti o Comunicazioni
- Stereoselective interaction at the BzR by some chiral N-(indol-3-ylglyoxylyl)amine derivatives 1997
- 2-Phenyl[1,2,3]triazole[1,2-a][1,2,4]benzotriazin-1,5(6H)-dione: a derivative of a new tricyclic heteroaromatic system with high affinity at the benzodiazepine receptor. 1998
- 5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a new class of A2A and A3 adenosine receptors antagonists 1999
- Interaction at BzR of closed-chain anlogues of N-benzyl-indol-3-ylglyoxylylamide derivatives 1999
- 3-aryl-[1,2,4]triazino[4,3-a]benzoimidazol-4(10H)-ones: selective A1 adenosine receptor antagonists 2000
- Derivati indol-3-ilgliossililammidici a catena chiusa otticamente attivi: possibilità di due diversi modi di legame al recettore centrale della benzodiazepine. 2000
- Indol-3-ylglyoxylilamide derivatives probing the existence of a hydrogen acceptor/donor group in the S1 region of the benzodiazepine receptor binding site 2000
- N,N-dialkyl-2-phenylindol-3-ylglyoxylamide derivatives: a new class of specific periferal-type benzodiazepine receptor ligands 2001
- [1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: a New Class of Selective Aldose Reductase Inhibitors 2001
- Nuovi derivati acidi acetici quali potenti inibitori dell'aldoso reduttasi. 2002
- 2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists. 2003
- N,N-Dialkyl-2-Phenylindol-3-ylglyoxylylamide Derivatives: a new class of potent and selective "Peripheral-type" Benzodiazepine receptor ligands. 2003
- A 2-phenylindol-3-ylglyoxylammide derivative, a new-synthesized peripheral benzodiazepine receptor ligand, induces apoptosis in rat C6 glioma cells 2004
- Differenze nell’affinità di legame ai recettori adenosinici A1 bovino e umano nelle classi dei 3-aril[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-oni (ATBI) ed N-alchil ed N-acil-(2-fenilimidazo[1,2-a][1,3,5]triazin-4-il)amine (ITA) 2004
- Ligandi ad alta affinità per il Recettore delle Benzodiazepine: Derivati del feniltriazolobenzotriazindione (PTBTs) 2004
- Progettazione e sintesi di nuovi derivati 2-fenilindol-3-ilgliossilamidici per un approfondimento delle relazioni struttura attività (SAR) di questa classe di ligandi potenti e selettivi per il PBR 2004
- Ricerca di ligandi selettivi per i sottotipi del recettore centrale delle benzodiazepine: nuovi derivati indolgliossilamidici 2004
- 2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists. 2005
- Asymetrically substituted N,N-dialkyl-2-phenylindol-3-ylglyoxylylamides as topological probes to explore the L3 and L4 lipophilic regions of the Peripheral Benzodiazepine Receptor site. 2005
- Novel highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-acitvity relationships and molecular modeling studies. 2005
- Studies in search for selective ligands for GABAA/BzR receptor subtypes: synthesis and biological evaluation of 4'-modified N-(benzyl)indol-3-ylglyoxylamides 2005
- New fluorescent probes for the pheripheral-type benzodiazepine receptor: synthesis and biological application 2006
- Synthesis and antiproliferative evaluation of new substituted Benzothiopyrano4,3-c condensed ring systems 2006
- Synthesis and biological evaluation of Pyrido1,2-apyrimidin-4-one derivatives as novel aldose reductase inhibitors exhibiting antioxidant activity 2006
- Synthesis and biological evaluation of modified 2-phenylindol-3-ylglyoxylamides as good candidates for the development of radioligands for the visualization of pheripheral benzodiazepine receptor 2007
- 3D-QSAR and virtual screening studies for the translocator protein(TSPO) 2008
- Development of new imaging tools targeting TSPO in related pathologies 2008
- Refinement of the mitochondrial translocator protein pharmacophore/receptor model via structure-activity relationships of novel N,N-dialkylindolylglyoxylamides. 2008
- Translocator Protein (TSPO) and identification of new molecular diagnosis tools 2008
- Characterization of a new irreversibile ligand to traslocator protein (18 KDa). 2009
- Design and synthesis of a novel irreversible fluorescent ligand for the visualization of Translocator Protein (18kDa). 2009
- Effect of typical and atypical antipsychotics on A2A adenosine receptor affinity and functional parameters in CHO transfected cells 2009
- Effects of TSPO-ligands on mitochondrial volume and on mitochondrial membrane potential. 2009
- Identification of new molecular diagnosis tools targeting the translocator protein (18kDa) 2009
- New oxazole and 1,2,4-oxadiazole derivatives as selective ligands at the Translocator Prootein (TSPO). 2009
- Novel 3-Aryl-1,2,4triazino4,3-abenzimidazol-4(10H)-ones (ATBI) as selective A2A adenosine receptor antagonists 2009
- Rational Design and Synthesis of Potent and Selective Adenosine Receptor Antagonists 2009
- Substituted 2-Arylindolglyoxylamides as potent translocator protein (18 kDa) TSPO ligands: synthesis and biological evaluation. 2009
- Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo3,4-Dpyrimidine adenosine A3 receptor antagonists. 2009
- Targeting the Translocator protein (TSPO) with 2-phenylindol-3-ylglyoxylamide derivatives. 2009
- Translocator protein (TSPO): biological characterization by using irreversibile TSPO ligands 2009
- 1-(PHENYLSULPHONAMIDO)-PYRAZOLE DERIVATIVES AS CARBONIC ANHYDRASE INHIBITORS. 2010
- Mitochondrial permeability transition: identification of new chemotherapy target and moleculardiagnosis tools 2010
- SYNTHESIS, ANTIPROLIFERATIVE ACTIVITY AND VEGFR-2 INHIBITION OF NEW ANILINO SUBSTITUTED THIOPYRANO-FUSED PYRIMIDINES. 2010
- 3-Aryl-1,2,4triazino4,3-abenzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. 2011
- Refinement of the Translocator Protein Pharmacophore/Receptor Model via Structure-activity Relationships of Novel N,N-Dialkylindolylglyoxylamides 2011
- Capitoli, Parte,Saggi, Studi, Articoli in libro
- 8th Chapt: Cell survival/death processes: Role of the mitochondrial Tranlocator Protein (TSPO) ligands - New Perspective in Medicinal Chemistry. 2009
- Design, synthesis, and biological evaluation of novel fluorescent probes targeting the Translocator Protein (18 kDa) (TSPO) - New Perspectives in Medicinal Chemistry 2009
- Novel classes of potent and selective antagonists at the A1 and A3 adenosine receptors designed by database searching and molecular simplification - New perspectives in medicinal chemistry 2009